Telomeric Repeat-Containing RNA.
TERRA
Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways.
Telomeres are transcribed into telomeric repeat-containing RNA (TERRA), large, heterogeneous, noncoding transcripts which form part of the telomeric heterochromatin. Despite a large number of functions that have been ascribed to TERRA, little is known about its biogenesis. The group of Prof. Joachim Lingner (ISREC - Lingner-lab) present the first comprehensive analysis of the molecular structure of TERRA. They identify biochemically distinct TERRA complexes, and describe TERRA regulation during the cell cycle.
Porro A. et al., Molecular and Cellular Biology Vol. 30, No. 20, p. 4808-4817 (2010)