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Structure‐function analysis of Editing Enzymes.

Jumping Genes

Jumping Genes

Structure‐function analysis points to a polynucleotide‐accommodating groove essential for APOBEC3A restriction activities.

The group of Prof. Didier Trono (LVG - Laboratory of Virology and Genetics) showed that the target-specificity of APOBEC3 family members - editing enzymes that can inhibit various mobile genetic elements -  is partly defined by structural features influencing their interaction with polynucleotide substrates.

Yannick Bulliard et al., J. Virol., doi:10.1128/JVI.01651-10 (2010)

Auteur: Caroline Vandevyver