Sandrine Gerber gives a keynote lecture at the GSENN2022
GSENN2022 speakers© S. Ameelia / GSENN 2022
Sandrine Gerber participated in the 2nd Global Summit and Expo on Nanotechnology and Nanomaterials in Copenhagen, Denmark, 13-15 June 2022.
She gave a keynote lecture entitled "Functionalized Harmonic Nanoparticles for Controlled Drug Release and Targeted Bioimaging Applications"
Abstract of the talk
Harmonic nanoparticles (HNPs), which are composed by non-centrosymmetric inorganic nanocrystals presenting a highly efficient non-linear response, have recently emerged in multiphoton imaging applications with the aim of overcoming some limitations of fluorescent probes [1]. In particular, HNPs exhibit several favorable properties for bioimaging applications such as i) the ability to image their second harmonic signal in response to excitation from the UV to mid-IR; ii) the absence of photo-bleaching, blinking and saturation; and iii) their spectrally narrow emission signals. Taking advantage of these properties, we recently demonstrated the suitability of HNPs (BiFeO3, BFO or LiNbO3, LNO) HNPs to be coated with a silica shell and post-functionalized with targeting ligands or molecular payloads for cancer cell and tissue imaging [2], stem cell tracking [3] and on-demand uncaging applications [4].
Herein, we present effective NIR light responsive nanocarriers based on LNO HNPs conjugated to anticancer drugs and analogues, using a coumarin derivative as photoresponsive tether. The inherent flexibility of HNPs with respect to the excitation wavelength, associated with the possibility to apply double excitation protocols, make them ideal systems for light-triggered release applications. Another recent development of functionalized LNO HNPs made use of covalent conjugation with Gd3+ chelates for dual optical and magnetic resonance imaging. The design of tailored surface chemical modifications of HNPs paves the way toward theranostic nanoplatforms combining highly sensitive diagnosis capacity with on-demand controlled drug delivery and treatment monitoring through multimodal imaging capabilities.
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L. Dubreil, I. Leroux, M. Ledevin, C. Schleder, L. Lagalice, C. Lovo, R. Fleurisson, S. Passemard, V. Kilin, S. Gerber-Lemaire, A. M. Colle, L. Bonacina, K. Rouger, ACS Nano, 11, 6672 – 6681 (2017).
J. Vuilleumier, G. Gaulier, R. De Matos, D. Ortiz, L. Menin, G. Campargue, C. Mas, S. Constant, R. Le Dantec, Y. Mugnier, Bonacina, S. Gerber-Lemaire, ACS Appl. Mater. Interfaces, 11, 27443 – 27452 (2019).