NAD+-dependent deacetylases and myelination.
© 2011 EPFL
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. The group of Prof. Johan Auwerx (LISP - Laboratory of Integrative Systems Physiology), in collaboration with researchers from the Washington University School of Medicine, previously used global expression profiling to examine peripheral nerve myelination and identified the NAD+-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, they show that Sirt2 expression in SCs is correlated with that of structural myelin components during both developmental myelination and remyelination after nerve injury.
Bogdan Beirowski et al., PNAS, doi: 10.1073/pnas.1104969108 (2011)