Just out in Nature Methods!
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Work done at the LND reveals that laser flash melting of cryo-samples can be used to overcome preferred particle orientation, an important bottleneck for protein structure determination by cryo electron microscopy. Read the full story here!
Preferred orientation often poses a significant challenge in obtaining protein structures using Cryo-EM. In our work just released in Nature Methods, we show how to overcome the preferred orientation by using laser flash melting of the cryo samples.