Genomic Variation in Drosophila melanogaster.
© 2012 EPFL
Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster.
"Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model organism populations are required. Here, the group of Prof. Bart Deplancke (Laboratory of Systems Biology and Genetics) presents a nucleotide resolution catalog of single-nucleotide, multi-nucleotide, and structural variants in 39 Drosophila melanogaster Genetic Reference Panel inbred lines. Using an integrative, local assembly-based approach for variant discovery, they identify more than 3.6 million distinct variants, among which were more than 800,000 unique insertions, deletions (indels), and complex variants (1 to 6,000 bp)."