Congratulations to Simon for his publication in Nanomaterials!
Graphical abstract - 2026 EPFL/Simon Dumolard
We are very pleased to share that our study on the development of multimodal imaging probes based on functionalized harmonic nanoparticles has just been released in Nanomaterials. This project was developed in collaboration with MER Dr Anne-Sophie Chauvin (EPFL, LCS), the team of Prof. Luigi Bonacina (Unige, Nonlinear BioImaging LAB) and the CIBM (Dr Kartarzyna Pierzchala, Dr Bernard Lanz). We are grateful to the group of Prof. Yannick Mugnier for providing harmonic nanocrystals and Dr Jérémie Teyssier for giving access to his microscopy platform.
In this work, entitled "Click Chemistry Functionalization of Harmonic Nanoparticles with Lanthanide Complexes Towards Tunable Platforms for Multimodal Imaging", Simon Dumolard developed conjugation pathways to immobilize Gd, Eu, Yb and Tb complexes at the surface of silica-peptide coated lithium niobate (LiNbO3) nanoparticles. Investigation of their nonlinear optical response and photophysical properties revealed that: i) their harmonic generation can be leveraged to simultaneously produce complementary optical signals using a single excitation; and ii) the surface-conjugated complexes can be recycled to change the lanthanide center depending on the desired imaging signature.
This study was funded by the Swiss National Science Foundation (DARE, grant No. 200021E_205745), the French Agence Nationale de la Recherche (DARE, grant No. ANR-21-CE09-0036-01), and the Swiss National Science Foundation Spark project CRSK-2_227400.
Dumolard, S.; Multian, V.; Gheata, A.; Spada, A.; Pierzchala, K.; Lanz, B.; Dhouib, A.; Mugnier, Y.; Teyssier, J.; Bonacina, L.; et al. Click Chemistry Functionalization of Harmonic Nanoparticles with Lanthanide Complexes Towards Tunable Platforms for Multimodal Imaging. Nanomaterials 2026, 16, 591. https://doi.org/10.3390/nano16100591.