Blandine Vergier successfully passed her candidacy exam
© 2021 EPFL LBMM
On October 19th, Blandine Vergier succeeded her candidacy exam. This is a very promising first step for the success of her PhD.
Mrs. Vergier joined the LBMM laboratory in October 2020 to work on a project entitled "Development of a microfluidic pipeline to decipher the target landscape of tumor-specific T Cell Receptors".
The principal goal of Mrs Vergier's PhD project is to establish a platform for the high-throughput interrogation of T cell’s target landscape via interaction with target cells. For that puropose, single T cells:APC pairs will be co-encapsulated in droplets, followed by fluorescent-based selective pico-injection of the droplets containing a reactive T cell with reagents for cell lysis and one-step reverse transcription and polymerase chain reaction (RT-PCR). TCR gene sequence and antigen will be retrieved and fused together by RT-PCR in droplets, followed by next-generation sequencing (NGS) analysis to identify pairs of matching TCR:antigen.
The project is funded by SNF throught a Sinergia project in collaboration with UNIL and CHUV (Grant CRSII5_193749)