Bisphenol A exposure increase the risk for breast cancer...

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ISREC professor, Cathrin Brisken (Head of the Lab working on Genetic dissection of signaling pathways in breast development and breast cancer), in collaboration with Dr Jacques Rougemont (Bioinformatics and Biostatistics Core Facility) and colleagues, confirm that perinatal exposure to Bisphenol A increases adult mammary gland Progesterone response and cell number...

Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic compound, it is currently utilized to manufacture food and beverage containers resulting in uptake with food and drinks. There is concern that exposure to low doses of BPA, defined as less than or equal to 5 mg/kg body weight /d, may have developmental effects on various hormone-responsive organs including the mammary gland. The group of Prof. Cathrin Brisken in collaboration with Dr. Jacques Rougemont (BBCF Core facility) and researchers from Geneva, France and Turkey asked whether perinatal exposure to a range of low doses of BPA is sufficient to alter mammary gland hormone response later on in life, with a possible impact on breast cancer risk. Their results show that perinatal exposure to environmentally relevant doses of BPA alters long-term hormone response that may increase the propensity to develop breast cancer.

Sept 29, 2011: Prof. Brisken on the Swiss TV to explain the risks of BPA (in French) - Prof. André-Pascal Sappino's interview (French)

The publication: Ayyakkannu Ayyanan et al., Molecular Endocrinology, doi: 10.1210/me.2011-1129 (2011)