A new model of brain metabolism.
© 2011 par UCSD Science & Engineering Library
A two-compartment mathematical model of neuroglial metabolism using [1-11C] acetate.
Compared with 13C MRS studies, 11C radiotracer measurements provide a single uptake curve representing the sum of all labeled metabolites, without chemical differentiation, but with higher temporal resolution. The group of Prof. Rolf Gruetter (CIBM - Center for Biomedical Imaging) propose in this study a two-compartment metabolic model of brain metabolism to assess oxidative metabolism from [1-11C] acetate radiotracer experiments, using an approach previously applied in 13C magnetic resonance spectroscopy (MRS), and compared with an one-tissue compartment model previously used in brain [1-11C] acetate studies.
Bernard Lanz et al.,Journal of Cerebral Blood Flow & Metabolism; doi: 10.1038/jcbfm.2011.162 (2011)