Modeling and visualizing stem cell dynamics
© 2012 EPFL
To explain and understand the impact of physical constraints on stem cell dynamics in general, and in the cornea in particular, our lab contributed expertise in geometric modeling and visualization to the existing procedures and experiments in professor Yann Barrandon's laboratory in the School of Life Sciences.
We developed models that became transdisciplinary repositories of data and fundamental collaborative research tools. This collaboration led to common thesis direction and to a publication. We also assembled a collaborative network to investigate how shape and physical environment affect stem cell behavior (and vice-versa) using a combination of state-of-the-art technologies from biology, optics, micro-engineering, architecture, civil engineering, photodynamic and signal processing in a project called Bio-architecture and Metrology.
F. Majo A. Rochat M. Nicolas G. Abou Jaoudé Y. Barrandon
Oligopotent stem cells are distributed throughout the ocular surface. Nature 456: 250-254. Epub 2008 oct 1. Research Highlights in Nature Reports Stem Cells Epub oct 9 2008 release.