IGM Colloquium: Period and Pattern in the Embryo
The segmentation clock is a multi-cellular patterning system of genetic oscillators thought to control the rhythmic and sequential formation of the vertebrate embryo's body segments. Individual oscillating cells are synchronized with their neighbors, forming a coherent wave pattern of gene expression.
How these wave patterns arise and how they are regulated during embryogenesis is not clear. I will describe recent progress in understanding the behavior of individual cells as they slow their oscillations and differentiate during segmentation, and discuss how this gives rise to the tissue-level wave patterns.
Andrew Oates received his Ph.D. at the Ludwig Institute for Cancer Research and the University of Melbourne. His postdoctoral time was at Princeton University and the University of Chicago in the lab of Robert Ho, where his studies on the segmentation clock in zebrafish began in 1998. In 2003 he moved to Germany and started his group at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden. In 2012 he accepted a position at University College London as Professor of vertebrate developmental genetics and moved his group to the MRC-National Institute for Medical Research at Mill Hill in London. From April 2015, he became a member of the Francis Crick Institute in London. In September 2016, he joined EPFL and his group is in the process of moving to Lausanne.