Histone Methyl Transferases and Demethylases
Histone methyl transferase
Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?
Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine residues, underlie these epigenetic phenomena, which impact on many physiological processes. The group of Prof. Johan Auwerx (LISP-Laboratory of Integrative Systems Physiology) illustrate that methyltranferases and demethylases affect many metabolic pathways. Preliminary evidence show that methyltranferases and demethylases could link metabolic signals to chromatin and alter transcription.