Hallucination Research Platform installed at WVU
The Blanke Lab at EPFL is delighted to announce that the WVU Rockefeller Neuroscience Institute (RNI) and Prof. Ali Rezai are now part of the research network investigating hallucinations in Parkinson’s disease. Our robotic device allowing to induce and investigate hallucinations in real-time in patients with Parkinson’s disease has arrived at West Virginia University.
Nearly half of the patients with Parkinson’s disease (PD) experience hallucinations, and recent studies have shown that hallucinations are associated with negative cognitive outcome and higher mortality. The Blanke Lab has been pioneering a robotic method to induce hallucinations in patients with PD to study the mechanisms behind this symptom. In a collaborative research effort they recently identified a subgroup of patients with increased sensitivity to hallucinations and used magnetic resonance to show that frontotemporal connectivity, associated with hallucinations in healthy participants, was disrupted in patients with PD suffering from hallucinations1. With the installation of the robotic platform this collaboration network is now extended to include the Rockefeller Neuroscience Institute at the West Virginia University.
We will study perception and consciousness and combine it with different neural measures. We will also continue the development of novel methods to induce such intriguing mental states.
BY FOSCO BERNASCONI, EVA BLONDIAUX, JEVITA POTHEEGADOO, GIEDRE STRIPEIKYTE, JAVIER PAGONABARRAGA, HELENA BEJR-KASEM, MICHELA BASSOLINO, MICHEL AKSELROD, SAUL MARTINEZ-HORTA, FREDERIC SAMPEDRO, MASAYUKI HARA, JUDIT HORVATH, MATTEO FRANZA, STÉPHANIE KONIK, MATTHIEU BEREAU, JOSEPH-ANDRÉ GHIKA, PIERRE R. BURKHARD, DIMITRI VAN DE VILLE, NATHAN FAIVRE, GIULIO ROGNINI, PAUL KRACK, JAIME KULISEVSKY, OLAF BLANKE
SCIENCE TRANSLATIONAL MEDICINE28 APR 2021
Presence hallucination in Parkinson’s disease (PD) is shown to arise from errors in sensorimotor integration and frontotemporal disconnection.