Detecting multiple drugs with an electrochemical biosensor.
© 2011 EPFL
Multi-panel drugs detection in human serum for personalized therapy.
The group of Prof. Giovanni De Micheli (LSI1 - Integrated Systems Laboratory) recently published in Biosensors and Bioelectronics the first world-wide demonstration on the possibility to detect multiple drugs with an electrochemical biosensor by using the same kind of probe proteins of the class Cytochromes P450. To succeed on that they also developed a new theoretical model on the drug/P450 interactions as observable in electrochemistry. They used carbon nanotubes to improve detection limit and they succeed in detecting the drugs in human serum. This outstanding result opens the possibility for totally new bio-nano-devices to be used in personalized therapy.
Sandro Carrara et al., Biosensors and Bioelectronics 26 (2011) 3914–3919