Cells respond to stress
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E2F transcription factor-1 regulates oxidative metabolism.
Cells respond to stress by coordinating proliferative and metabolic pathways. Starvation restricts cell proliferative (glycolytic) and activates energy productive (oxidative) pathways. Conversely, cell growth and proliferation require increased glycolytic and decreased oxidative metabolism levels. E2F transcription factors regulate both proliferative and metabolic genes. The group of Prof. Johan Auwerx (NCEM - Nestlé Chair in Energy Metabolism) shows that E2F1 represents a metabolic switch from oxidative to glycolytic metabolism that responds to stressful conditions.
Emilie Blanchet et al., Nature Cell Biology, doi:10.1038/ncb2309 (2011)