Agency Deficits in a Human Genetic Model of Schizophrenia

© LNCO / EPFL 2022

© LNCO / EPFL 2022

In a collaboration between the LNCO, the University (UniGe) and University Hospital of Geneva (HUG), as well as local community organisations (Connect 22, Génération 22, Relais 22), and led by Dr Roy Salomon and Dr Oliver Kannape, we have conducted two behavioural studies using full body motion capture and virtual reality feedback with a cohort of 22q11DS individuals that provide novel insights into abnormalities in motor awareness and the sense of agency in this genetic model of schizophrenia.

Abstract Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one's actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.


Swiss National Science Foundation Project Funding Grant No. 144260
SNSF National Center of Competence in Research Grant No. 185897
SNSF Sinergia Grant No. 125135
The Bertarelli Foundation